PURPOSE There is an unmet need for new systems with quantitative pancreatic imaging assessments to support better diagnosis and understand development of chronic pancreatitis (CP). The aims were to present such an approach for assessment of imaging features in CP, to apply this system in a multi-center cohort of CP patients (feasibility study), and to report inter-reader agreement between expert radiologists (validation study). METHODS The feasibility study included pancreatic computed tomography (CT) or magnetic resonance imaging (MRI) from 496 patients with definitive CP in the Scandinavian Baltic Pancreatic Club (SBPC) database. Images were assessed according to the new SBPC imaging system (quantitative assessments of ductal and parenchymal features). Inter-reader agreement of reported imaging parameters was investigated for 80 CT and 80 MRI examinations by two expert radiologists. RESULTS Reporting of the imaging features into the imaging system was deemed feasible for > 80% of CT and > 90% of MRI examinations. Quantitative assessments of main pancreatic duct diameters, presence/number/diameter of calcifications, and gland diameters had high levels of inter-reader agreement with κ-values of 0.75-0.87 and intraclass correlation coefficients of 0.74-0.97. The more subjective assessments, e.g., irregular main pancreatic duct and dilated side-ducts, had poor to moderate agreement with κ-values of 0.03-0.44. CONCLUSION The presented system provides a feasible mean for systematic assessment of CP imaging features. Imaging parameters based on quantitative assessment, as opposed to subjective assessments, have better reproducibility and should be preferred in the development of new grading systems for understanding pathophysiology and disease progression in CP.

中文翻译：

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评估慢性胰腺炎影像学特征的系统方法：来自斯堪的纳维亚波罗的海胰腺俱乐部（SBPC）数据库的可行性和验证研究。

目的对具有定量胰腺成像评估的新系统的需求尚未得到满足，以支持更好的诊断和了解慢性胰腺炎（CP）的发展。目的是提出一种评估CP成像特征的方法，将该系统应用于CP患者的多中心队列（可行性研究），并报告专家放射科医生之间的读者间协议（验证研究）。方法可行性研究包括斯堪的纳维亚波罗的海胰腺俱乐部（SBPC）数据库中的496例确诊CP患者的胰腺计算机断层扫描（CT）或磁共振成像（MRI）。根据新的SBPC成像系统（对导管和实质特征进行定量评估）评估图像。两位专业放射科医生对80项CT和80项MRI检查研究了报告的成像参数的读者间一致性。结果对于大于80％的CT和大于90％的MRI检查，将成像特征报告到成像系统中被认为是可行的。对主要胰管直径，钙化的存在/数目/直径以及腺体直径的定量评估具有较高的读者内部一致性水平，κ值为0.75-0.87，组内相关系数为0.74-0.97。较主观的评估，例如不规则的主胰管和扩张的副干，与κ值为0.03-0.44的一致性差至中度。结论提出的系统为CP成像特征的系统评估提供了可行的手段。基于定量评估的成像参数