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PD1 Blockade in Cancer: Impact on Myeloid Cells.
Trends in Cancer ( IF 18.4 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.trecan.2020.02.018 Mai Fujiwara 1 , Lucien P Garo 1 , Gopal Murugaiyan 1
中文翻译:
PD1癌症阻滞:对髓样细胞的影响。
更新日期:2020-03-13
Trends in Cancer ( IF 18.4 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.trecan.2020.02.018 Mai Fujiwara 1 , Lucien P Garo 1 , Gopal Murugaiyan 1
Affiliation
Programmed death 1 (PD1) has emerged as a major inhibitor of antitumor T cells, and anti-PD1 therapies have demonstrated clinical efficacy in multiple cancers. However, the impact of PD1 on other immune cells had remained unclear. A recent study by Strauss et al. describes how myeloid cell-intrinsic PD1 signaling limits myelopoiesis in cancer pertinent to anti-PD1 therapies.
中文翻译:
PD1癌症阻滞:对髓样细胞的影响。
程序性死亡1(PD1)已成为抗肿瘤T细胞的主要抑制剂,并且抗PD1治疗已在多种癌症中证明了临床疗效。但是,PD1对其他免疫细胞的影响仍不清楚。Strauss等人的最新研究。描述了髓样细胞内源性PD1信号转导如何限制与抗PD1疗法有关的癌症中的骨髓生成。