The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5 methyltransferase (U5MT), TRMT2A, and its interaction with 5-FU metabolites incorporated within tRNAs, lead to an additional hypothesis that is proposed here.

中文翻译：

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关于5-氟尿嘧啶介导的细胞毒性的新机制的研究。

通常认为细胞毒性药物5-氟尿嘧啶（5-FU）的主要分子作用模式是由胸苷酸合酶抑制引起的。有关人类尿嘧啶5甲基转移酶（U5MT），TRMT2A的功能及其与tRNA中掺入的5-FU代谢物的相互作用的最新发现导致了此处提出的另一种假设。