Objective/background

Currently, obstructive sleep apnea syndrome (OSAS) management in Robin sequence (RS) infants has not been standardized. Sleep laboratory polysomnography (PSG) is the gold standard for OSAS diagnosis, however, access is restricted. This study aimed to compare the respiratory indexes measured in a sleep laboratory using PSG as well as a possible alternative, polygraphy (PG).

Patients/methods

This retrospective study was conducted between 2015 and 2017 in a tertiary hospital. PSG performed in RS infants in the sleep laboratory was analysed by a single reviewer. After sleep data removal, anonymized raw data were analysed to obtain only PG data. Respiratory indexes were compared for (i) PSG and PG and (ii) patients with or without OSAS clinical signs.

Results

Among the 20 RS (median [IQR] age: 43 [25–114] days at evaluation), 70% of the patients had OSAS clinical signs but all of them had severe OSAS. The median mixed obstructive apnea hypopnea index was not significantly different between PSG and PG (27/h [18–38] versus 26/h [18–56], p = 0.43). The median obstructive apnea index was higher with no significant difference between PG and PSG (19/h [15–31] versus 7/h [4–25], p = 0.05). The median obstructive hypopnea index was significantly lower on PG than on PSG (2/h [0–3] versus 8/h [8–19], p = 0.01). No difference on PSG or PG was observed for patients with and without clinical signs of OSAS.

Conclusion

Although PSG remains the gold standard for OSA evaluation, a PG seems to be a useful alternative to measure OSA in RS infants because of their OSAS severity. This evaluation should be recommended in all RS infants, even in the absence of OSAS clinical signs.

Clinical trial registration

Not applicable.

中文翻译：

---

睡眠实验室测谎在评估Robin婴儿阻塞性睡眠呼吸暂停综合症中的作用。

目标/背景

目前，Robin序列（RS）婴儿的阻塞性睡眠呼吸暂停综合症（OSAS）管理尚未标准化。睡眠实验室多导睡眠图（PSG）是OSAS诊断的金标准，但是，访问受到限制。这项研究旨在比较在睡眠实验室中使用PSG以及可能的另一种测谎仪（PG）测得的呼吸指数。

患者/方法

这项回顾性研究于2015年至2017年之间在一家三级医院进行。一位审阅者对在睡眠实验室的RS婴儿中进行的PSG进行了分析。删除睡眠数据后，将分析匿名原始数据，仅获得PG数据。比较了（i）PSG和PG以及（ii）有或没有OSAS临床体征的患者的呼吸指数。

结果

在20个RS（评估中位[IQR]年龄：43 [25–114]天）中，有70％的患者患有OSAS临床体征，但所有患者均患有严重的OSAS。PSG和PG的中位混合阻塞性呼吸暂停低通气指数无明显差异（27 / h [18-38]与26 / h [18-56]，p  = 0.43）。中位阻塞性呼吸暂停指数较高，PG和PSG之间无显着差异（19 / h [15-31]比7 / h [4-25]，p  = 0.05）。PG的中位阻塞性呼吸不足指数显着低于PSG（2 / h [0-3]比8 / h [8-19]，p  = 0.01）。有或没有OSAS临床体征的患者在PSG或PG上均无差异。

结论

尽管PSG仍然是OSA评估的金标准，但PG由于其OSAS严重性，似乎是衡量RS婴儿OSA的有用替代方法。即使没有OSAS临床体征，也应建议所有RS婴儿进行该评估。

临床试验注册

不适用。