Eight unexpected vibralactone homodimers, bisvibralactones A-H (1-8), and three new vibralactone monomers, hirsutumins A-C (9-11), were isolated from the culture of Stereum hirsutum. Their structures and absolute configurations were determined by detailed analyses of NMR, optical rotations, ECD, and high-resolution mass spectra as well as chemical transformation. Compounds 1-8 are unusual vibralactone dimers formed by the esterification of two vibralactone monomers. The absolute configurations of compounds 1 and 5 were determined by chemical conversions. All of the isolated compounds were evaluated for Porcine Pancreatic Lipase (PPL) inhibitory activities, and compound 10 showed significant inhibitory activity against PPL, with an IC50 value of 8.31 ± 1.04 μM.

中文翻译：

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真菌Shirum hirsutum产生的结构上不同的异戊内酯。

从Shirum hirsutum的培养物中分离出八种出人意料的vibralactone同型二聚体，bisvibralactones AH（1-8）和三种新的vibralactone单体hirsutumins AC（9-11）。它们的结构和绝对构型是通过对NMR，旋光，ECD和高分辨率质谱以及化学转化的详细分析确定的。化合物1-8是通过两个vibralactone单体的酯化反应形成的不寻常的vibralactone二聚体。化合物1和5的绝对构型通过化学转化来确定。评价所有分离的化合物的猪胰脂肪酶（PPL）抑制活性，化合物10对PPL表现出显着的抑制活性，IC50值为8.31±1.04μM。