Insulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in many cell types. The translocation of GLUT4 from intracellular membranes to the cell surface is often described as a highly specialised form of membrane traffic restricted to certain cell types such as fat and muscle, which are the major storage depots for insulin-stimulated glucose uptake. Here, we discuss evidence that favours the argument that rather than being restricted to specialised cell types, the machinery through which insulin regulates GLUT4 traffic is present in all cell types. This is an important point as it provides confidence in the use of experimentally tractable model systems to interrogate the trafficking itinerary of GLUT4.

中文翻译：

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胰岛素刺激的GLUT4易位-大小并非决定一切！

在许多细胞类型中都研究了胰岛素调节的葡萄糖转运蛋白GLUT4的运输。GLUT4从细胞内膜到细胞表面的转运通常被描述为膜运输的高度专业化形式，仅限于某些细胞类型，例如脂肪和肌肉，它们是胰岛素刺激的葡萄糖摄取的主要储存库。在这里，我们讨论了支持以下论点的证据，即，胰岛素调节GLUT4流量的机制存在于所有细胞类型中，而不是局限于特定的细胞类型。这一点很重要，因为它为使用实验易处理的模型系统询问GLUT4的交易路线提供了信心。