Obesity is associated with inflammation and oxidative stress. Bioactive compounds can decrease obesity-related disorders by their antioxidant and anti-inflammatory actions. Wistar rats were fed with a high-fat diet during 14 weeks and received 100 mg of wine pomace product (WP)/kg body weight, from the 1st week or from the 7th week and standard diet fed rats were included. Food intake, body weight, blood pressure and plasma glucose, cholesterol and triglyceride were weekly measured. Antioxidant and lipid liver status, fat, adipocyte size, plasma interleukins and microbiota were also determined at 14th week. The results showed a significant reduction of body weight and abdominal fat area, lower blood glucose, decreased liver weight and lipids deposition with increased antioxidant status, lower adipocyte size and increased Lactobacillus spp./Bacteroides spp. ratio. Therefore, wine pomace product reduced obesity-related disorders by amelioration of inflammation and oxidative stress and by microbiota regulation suggesting potential preventive clinical benefits.

肥胖与炎症和氧化应激有关。生物活性化合物可通过其抗氧化剂和抗炎作用减少与肥胖有关的疾病。从第1周或第7周起，Wistar大鼠在14周内接受高脂饮食喂养，并接受100 mg酒渣产品（WP）/ kg体重，并包括标准饮食喂养的大鼠。每周测量食物摄入量，体重，血压和血浆葡萄糖，胆固醇和甘油三酸酯。在第14周也测定抗氧化剂和脂质肝的状态，脂肪，脂肪细胞大小，血浆白介素和微生物群。结果表明，体重和腹部脂肪面积显着减少，血糖降低，肝脏重量和脂质沉积减少，抗氧化剂状态增强，脂肪细胞尺寸减小，脂肪含量增加。乳杆菌属/拟杆菌属 比。因此，葡萄酒渣渣产品通过改善炎症和氧化应激以及通过微生物群调节减少了与肥胖有关的疾病，从而暗示了潜在的预防性临床益处。