To investigate the dose-effect relationship of sea cucumber peptides on memory function improvement, animal experiments, behavioral experiments, ACh content, AChE activity, hippocampal morphology, and protein modifications were detected. Sea cucumber peptides (650 mg/kg, 1300 mg/kg, 2600 mg/kg body weight) and piracetam (400 mg/kg) were gavaged into the mice. Scopolamine (5 mg/kg) were administered intraperitoneally to mice. In behavioral experiments, the escape latency and the shocked time of sea cucumber peptides (SCP) groups were significantly reduced (P < 0.05). Determination of biochemical indicators found that ACh content and AChE activity of SCP groups were increased (P < 0.05). The number of neurons in the hippocampus of SCP groups were larger, arranged neatly and intact. The histone acetyltransferases activity of SCP groups may be lower than that of the Scopolamine group, so the acetylation level is down-regulated and approached to dynamic equilibrium, thereby the memory activity of mice was improved.

为了研究海参肽对记忆功能改善的剂量-效应关系，检测了动物实验，行为实验，ACh含量，AChE活性，海马形态和蛋白质修饰。将海参肽（650 mg / kg，1300 mg / kg，2600 mg / kg体重）和吡拉西坦（400 mg / kg）注入小鼠体内。向小鼠腹膜内给予东pol碱（5mg / kg）。在行为实验中，海参肽（SCP）组的逃避潜伏期和震惊时间显着减少（P  <0.05）。生化指标的测定发现SCP组的ACh含量和AChE活性增加（P <0.05）。SCP组海马中的神经元数量更大，排列整齐且完整。SCP组的组蛋白乙酰转移酶活性可能低于东pol碱组，因此乙酰化水平被下调并达到动态平衡，从而提高了小鼠的记忆活性。