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Nucleotide second messengers in bacterial decision making.
Current Opinion in Microbiology ( IF 5.4 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.mib.2020.02.006
Catriona Ma Thompson 1 , Jacob G Malone 1
Affiliation  

Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is tightly controlled at every regulatory level. They function as global regulators and in specific signalling circuits, controlling multiple aspects of bacterial behaviour and development. Despite these advances there is much still to discover, with current research focussing on the molecular mechanisms of signalling circuits, the role of the environment in controlling NSM pathways and attempts to understand signalling at the whole cell/community level. Here we examine recent developments in the NSM signalling field and discuss their implications for understanding this important driver of microbial behaviour.

中文翻译:

细菌决策中的核苷酸第二信使。

自从最初发现细菌核苷酸第二信使(NSM)以来,我们在理解这些复杂的信号网络方面取得了巨大的进步。许多NSM网络包含数十种代谢酶和结合靶标,它们的活性在每个调节水平上都受到严格控制。它们充当全局调节剂,并在特定的信号回路中发挥作用,控制细菌行为和发育的多个方面。尽管取得了这些进展,但仍有许多发现,目前的研究集中在信号传导电路的分子机制,环境在控制NSM途径中的作用以及试图了解整个细胞/社区水平的信号传导。
更新日期:2020-03-16
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