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Antibacterial bisabolane sesquiterpenoids and isocoumarin derivatives from the endophytic fungus Phomopsis prunorum
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2020-03-14 , DOI: 10.1016/j.phytol.2020.03.003
Hui-Rong Qu , Wen-Wen Yang , Xue-Qing Zhang , Zhen-Hong Lu , Zhang-Shuang Deng , Zhi-Yong Guo , Fei Cao , Kun Zou , Peter Proksch

A pair of new phenolic bisabolane-type sesquiterpenoid enantiomers (±)- phomoterpenes A and B [(±)-1] and two known analogues (2 and 3), together with two new isocoumarins, phomoisocoumarins C‒D (45), were isolated from an endophytic fungus Phomopsis prunorum (F4-3). Their structures were elucidated by comprehensive spectroscopic analysis. The enantiomeric separation for (±)-1 were achieved by chiral-HPLC, and their absolute configurations were assigned by electronic circular dichroism (ECD) calculation. Compounds (+)-1 and 5 exhibited moderate antibacterial activity against plant pathogenic bacteria Pseudomonas syringae pv. Lachrymans with MIC values of 15.6 μg/mL.



中文翻译:

内生真菌Phomopsis prunorum的抗菌双杂草醚倍半萜和异香豆素衍生物

一对新的酚类bisabolane型倍半萜类对映异构体(±) - phomoterpenes甲乙[(±) - 1 ]和两个已知类似物(23)中,用两种新的异香豆素一起,phomoisocoumarins C-d(4 - 5)从内生真菌Pomopsis prunorum(F4-3)中分离出。通过全面的光谱分析阐明了它们的结构。(±)-1的对映异构体分离通过手性HPLC实现,其绝对构型通过电子圆二色性(ECD)计算确定。化合物(+)- 15对植物病原菌表现出中等的抗菌活性丁香假单胞菌PV。Lachrymans 15.6 MIC值μ克/毫升。

更新日期:2020-03-16
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