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Aromatic Amino Acids: A Complex Network Ripe for Future Exploration.
Trends in Plant Science ( IF 20.5 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.tplants.2020.02.005
Joseph H Lynch 1 , Natalia Dudareva 2
Affiliation  

In plants, high carbon flux is committed to the biosynthesis of phenylalanine, tyrosine, and tryptophan, owing to their roles not only in the production of proteins, but also as precursors to thousands of primary and specialized metabolites. The core plastidial pathways that supply the majority of aromatic amino acids (AAAs) have previously been described in detail. More recently, the discovery of cytosolic enzymes contributing to overall AAA biosynthesis, as well as the identification of intracellular transporters and the continuing elucidation of transcriptional and post-transcriptional regulatory mechanisms, have revealed the complexity of this intercompartmental metabolic network. Here, we review the latest breakthroughs in AAA production and use the newest findings to highlight both longstanding and newly developed questions.



中文翻译:

芳香氨基酸:一个复杂的网络,有待进一步探索。

在植物中,高碳通量致力于苯丙氨酸,酪氨酸和色氨酸的生物合成,这是由于它们不仅在蛋白质生产中起着作用,而且还作为数千种主要和专门代谢产物的前体起作用。以前已经详细描述了提供大多数芳香族氨基酸(AAA)的核心质体途径。最近,发现有助于整体AAA生物合成的胞质酶,以及细胞内转运蛋白的识别以及转录和转录后调控机制的不断阐明,揭示了这种室间代谢网络的复杂性。在这里,我们回顾了AAA生产的最新突破,并使用最新发现来强调长期存在和新开发的问题。

更新日期:2020-03-13
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