Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment. The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed eight weeks’ treatment of escitalopram were included in the final statistics. Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment. For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) of δ1 band (0.5 - 2 Hz), accompanied by a significant decrease in the RE of β2 band (20 - 30 Hz). Lempel-Ziv complexity and Co - complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as throughout the night sleep. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry. Regarding band-specific EEG complexity estimations, δ1 and β2 in stage-1 and δ1 in stage-2 sleep stage in frontal cortex is found to be much more sensitive to escitalopram treatment in comparison to central and occipital cortices. The sleep quality of MDD patients improved, EEG response occurred asymmetry in left and right hemispheres due to escitalopram treatment, and frontal cortex is found to be much more sensitive to escitalopram treatment. These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

中文翻译：

---

艾司西酞普兰治疗后重度抑郁症睡眠期间脑电图特征的时空动态：一项初步研究。

先前的研究表明艾司西酞普兰与睡眠质量有关。然而，艾司西酞普兰对脑电图（EEG）特征动态的影响，特别是在不同睡眠阶段的影响尚未见报道。这项研究可能有助于揭示艾司西酞普兰治疗的药理学机制。本研究分析了重度抑郁症（MDD）患者对艾司西酞普兰治疗的空间和时间反应。最终统计数据包括完成八周艾司西酞普兰治疗的 11 名 MDD 患者和 11 名健康对照受试者。在睡眠期间获取六通道睡眠脑电图信号。采用功率谱和非线性动力学分析艾司西酞普兰治疗后睡眠脑电图的时空动力学特征。对于时间动态：治疗后，δ1带（0.5 - 2 Hz）的相对能量（RE）显着增加，同时β2带（20 - 30 Hz）的RE显着下降。Lempel-Ziv 复杂度和 Co 复杂度值显着降低。不同睡眠阶段的脑电图变化也表现出与整个夜间睡眠相同的调节。对于空间动力学：治疗后，左右半球的脑电图反应表现出不对称。关于特定频段脑电图复杂性估计，发现与中央和枕叶皮质相比，额叶皮质第一阶段睡眠阶段的 δ1 和 β2 以及第二阶段睡眠阶段的 δ1 对艾司西酞普兰治疗更加敏感。MDD患者的睡眠质量得到改善，艾司西酞普兰治疗导致左右半球脑电图反应出现不对称，并且发现额叶皮层对艾司西酞普兰治疗更加敏感。这些发现可能有助于全面了解艾司西酞普兰治疗抑郁症的药理学机制。