The aim of this study was to investigate the prevalence and genotypic profiles of Candida albicans in patients with oral lichen planus (OLP). Positive rates and genotypic profiles of Candida albicans strains from OLP patients and healthy controls were analyzed. Random amplified polymorphic DNA and internal transcribed spacer of ribosome DNA polymerase chain reactions were used to sequence the DNA of these strains, and then their genetic similarity was measured using BLAST, UIV Band, and Vector NTI Suite Sequence Analyses Software. The prevalence of C. albicans strains detected from erosive-OLP, non-erosive OLP, and normal individuals was 18.87, 18.75, and 7.92%, respectively. Four different genotypes were revealed by the two methods. To be specific, type I was found only in the healthy subjects; type II a and II b were found in non-erosive OLP, and type III was identified in erosive OLP. Intragroup similarity coefficients, i.e. SAB were 100%, and inter-groups similarity coefficients, i.e. SAB were less than 30%. The genotypic results of C. albicans in OLP revealed an endogenous rather than exogenous infection of C. albicans. In addition, a possible pathogenic role of C. albicans in OLP, with the etiologic sense contributing to a more proper recognition on the pathogenesis, development, and progression of OLP, as well as some strategies for its diagnosis and treatment were identified.

中文翻译：

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一项初步研究：念珠菌可能是口腔扁平苔藓的病因内源性病原体。

这项研究的目的是调查口腔扁平苔藓（OLP）患者中白色念珠菌的患病率和基因型。分析了来自OLP患者和健康对照组的白色念珠菌菌株的阳性率和基因型谱。使用随机扩增的多态性DNA和核糖体DNA聚合酶链反应的内部转录间隔子对这些菌株的DNA进行测序，然后使用BLAST，UIV Band和Vector NTI Suite Sequence Analyzes Software测量其遗传相似性。从侵蚀性OLP，非侵蚀性OLP和正常个体中检测到的白色念珠菌菌株的患病率分别为18.87％，18.75％和7.92％。两种方法揭示了四种不同的基因型。具体而言，仅在健康受试者中发现了I型。在非侵蚀性OLP中发现了IIa和IIb型，在侵蚀性OLP中鉴定出III型。组内相似系数即SAB为100％，组间相似系数即SAB小于30％。白色念珠菌在OLP中的基因型结果表明，白色念珠菌是内源性感染，而不是外源性感染。此外，确定了白色念珠菌在OLP中可能的致病作用，其病因学意义有助于更正确地认识OLP的发病机理，发育和进程，以及一些诊断和治疗策略。