BACKGROUND Adolescence is a distinctive stage of various changes and is noted as peak age for onset of many psychiatric disorders, especially linked to stress and depression. Several genetic variations are being increasingly known to be linked with stress and depression. The polymorphisms in two such genes, the BDNF and SLC1A3, have been reported to be linked with either depression/stress or with suicidal behaviour. These genes have not been validated in Indian population, and therefore there is a need to investigate these genes in Indian population. The present study was undertaken to test whether the known polymorphisms SLC1A3 C3590T, SLC1A3 C869G and BDNF G196A are associated or not with stress or depression in an eastern Indian population. METHODS A case-control association study was performed with 108 cases having variable levels of stress and depression and 205 matched controls. Detection of stress and depression was done by using standard instruments as PSS and CES-D, respectively and demographic profile was obtained for each individual on the basis of personal data sheet. Genotyping for the selected polymorphisms was performed by PCR followed by restriction digestion. RESULTS The SNP SLC1A3 C3590T was found to be associated with stress and depression (p = 0.0042, OR = 2.072). Therefore, the T allele increases the risk by more than two folds for stress and depression in the present population. The other allele of SLC1A3, G869C, as well as BDNF G196A were not associated with stress or depression in the population studied. CONCLUSION SLC1A3 C3590T is a predisposition factor for stress and depression in an eastern Indian population, whereas SLC1A3 G869C and BDNF G196A were not found to be a risk factor. Therefore, presence of T allele of SLC1A3 C3590T, may predict the development of stress and depression in an individual. This may also help in the understanding of pathophysiology of the disease. However, these findings warrant a wider study in Indian populations and would be of significance in understanding the predisposition of stress and depression in this population.

中文翻译：

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SLC1A3 C3590T而不是BDNF G196A是印度东部青少年期的压力和抑郁症的诱因。

背景技术青春期是各种变化的一个独特阶段，被认为是许多精神疾病（尤其是与压力和抑郁症相关的疾病）发作的高峰年龄。越来越多的遗传变异与压力和抑郁有关。据报道，BDNF和SLC1A3这两个基因的多态性与抑郁症/压力或自杀行为有关。这些基因尚未在印度人口中得到验证，因此有必要在印度人口中研究这些基因。进行本研究以测试已知的多态性SLC1A3 C3590T，SLC1A3 C869G和BDNF G196A是否与印度东部人口的压力或抑郁相关。方法进行了病例对照研究，研究对象为108例压力和抑郁水平各不相同的患者和205名相匹配的对照。分别通过使用标准仪器PSS和CES-D进行压力和抑郁的检测，并根据个人数据表获取每个人的人口统计资料。通过PCR，然后进行限制性酶切，对选定的多态性进行基因分型。结果发现SNP SLC1A3 C3590T与压力和抑郁相关（p = 0.0042，OR = 2.072）。因此，T等位基因使当前人群的压力和抑郁风险增加了两倍以上。SLC1A3，G869C和BDNF G196A的其他等位基因与研究人群的压力或抑郁无关。结论SLC1A3 C3590T是印度东部人口压力和抑郁的诱因，而SLC1A3 G869C和BDNF G196A并不是危险因素。因此，SLC1A3 C3590T的T等位基因的存在可以预测个体的压力和抑郁情绪的发展。这也可能有助于了解该疾病的病理生理学。但是，这些发现值得在印度人群中进行更广泛的研究，对于理解该人群压力和抑郁的易感性具有重要意义。这也可能有助于了解该疾病的病理生理学。但是，这些发现值得在印度人群中进行更广泛的研究，对于理解该人群压力和抑郁的易感性具有重要意义。这也可能有助于了解该疾病的病理生理学。但是，这些发现值得在印度人群中进行更广泛的研究，对于理解该人群压力和抑郁的易感性具有重要意义。