Phosphorylation as a post-translational modification is critical for cellular homeostasis. Kinases and phosphatases regulate phosphorylation levels by adding or removing, respectively, a phosphate group from proteins or other biomolecules. Imbalances in phosphorylation levels are involved in a multitude of diseases. Phosphatases are often thought of as the black sheep, the strangers, of phosphorylation-mediated signal transduction, particularly when it comes to drug discovery and development. This is due to past difficulties to study them and unsuccessful attempts to target them; however, phosphatases have regained strong attention and are actively pursued now in clinical trials. By giving examples for current hot topics in phosphatase biology and for new approaches to target them, it is illustrated here how and why phosphatases made their comeback, and what is envisioned to come in the future.

中文翻译：

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转身面对奇怪：磷酸酶的新观点。

磷酸化作为翻译后修饰对于细胞稳态至关重要。激酶和磷酸酶通过分别从蛋白质或其他生物分子中添加或去除磷酸基团来调节磷酸化水平。磷酸化水平的失衡涉及多种疾病。磷酸酶通常被认为是磷酸化介导的信号转导的败类，是陌生人，特别是在药物发现和开发方面。这是由于过去研究它们的困难和针对它们的失败尝试；然而，磷酸酶已经引起了广泛的关注，并在临床试验中得到了积极的追求。通过举例说明当前磷酸酶生物学的热门话题以及针对它们的新方法，