Ficus hirta Vahl. (Wuzhimaotao) is an edible functional food used for the soup cooking and health products. Seven undescribed phenolic glycosides (1–7), along with 20 analogues, were isolated from the roots of Ficus hirta. Their structures were determined by comprehensive spectroscopic methods (UV, IR, HRESIMS, and NMR), while the absolute configuration of 1 was established by comparison of the experimental and calculated ECD data. The antineuroinflammatory effects of all the compounds were examined by Western blot. Compounds 1 and 11 attenuated the phosphorylation of AKT, JNK, and ERK1/2. In addition, compound 11 inhibited the NF-κB p65 phosphorylation. Our results indicated that compounds 1 and 11 decreased the occurrence of neuroinflammation in BV2 microglia cells, which might be regulated by inhibiting the activity of proteins in NF-κB, MAPK (JNK and ERK1/2), or AKT signaling pathways. Thus, 1 and 11 might exhibit antineuroinflammatory activities and show promise in treating neurodegenerative diseases.

中文翻译：

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从根中酚苷榕菊干旱胁迫下连翘。及其抗神经炎活性

榕古草干旱胁迫下连翘。（五子毛桃）是一种可食用的功能性食品，用于汤料烹饪和保健品。七未描述的酚苷（1 - 7）中，用20个类似物一起，被从根部分离榕古草。它们的结构通过综合光谱学方法（UV，IR，HRESIMS和NMR）确定，而1的绝对构型是通过比较实验数据和计算得出的ECD数据确定的。通过Western印迹检查所有化合物的抗神经炎作用。化合物1和11减弱了AKT，JNK和ERK1 / 2的磷酸化。另外，化合物11抑制NF-κBp65磷酸化。我们的结果表明，化合物1和11减少了BV2小胶质细胞中神经炎症的发生，这可能是通过抑制NF-κB，MAPK（JNK和ERK1 / 2）或AKT信号通路中蛋白质的活性来调节的。因此，1和11可能具有抗神经炎活性，并有望在神经退行性疾病的治疗中发挥作用。