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Review of injection techniques for spermatogonial stem cell transplantation
Human Reproduction Update ( IF 13.3 ) Pub Date : 2020-03-12 , DOI: 10.1093/humupd/dmaa003
Murat Gul 1, 2 , Simone Hildorf 3 , Lihua Dong 1 , Jorgen Thorup 3 , Eva R Hoffmann 4 , Christian Fuglesang S Jensen 5 , Jens Sønksen 5, 6 , Dina Cortes 6, 7 , Jens Fedder 8, 9 , Claus Yding Andersen 1, 6 , Ellen Goossens 10
Affiliation  

Although the prognosis of childhood cancer survivors has increased dramatically during recent years, chemotherapy and radiation treatments for cancer and other conditions may lead to permanent infertility in prepubertal boys. Recent developments have shown that spermatogonial stem cell (SSC) transplantation may be a hope for restoring fertility in adult survivors of childhood cancers. For this reason, several centres around the world are collecting and cryopreserving testicular tissue or cells anticipating that, in the near future, some patients will return for SSC transplantation. This review summarizes the current knowledge and utility of SSC transplantation techniques.

中文翻译:

精原干细胞移植注射技术综述

尽管近年来儿童癌症幸存者的预后大大增加,但针对癌症和其他疾病的化学疗法和放射治疗可能会导致青春期前男孩永久性不育。最近的发展表明,精原干细胞(SSC)移植可能是恢复儿童癌症成年幸存者生育能力的希望。因此,世界各地的一些中心正在收集和冷冻保存睾丸组织或细胞,并预期不久的将来一些患者将返回进行SSC移植。这篇综述总结了SSC移植技术的当前知识和实用性。
更新日期:2020-04-17
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