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Association of Neisseria gonorrhoeae Plasmids With Distinct Lineages and The Economic Status of Their Country of Origin
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-03-12 , DOI: 10.1093/infdis/jiaa003
Ana Cehovin 1 , Keith A Jolley 2 , Martin C J Maiden 2 , Odile B Harrison 2 , Christoph M Tang 1
Affiliation  

Plasmids are vehicles for horizontal gene transfer between bacteria, and in Neisseria gonorrhoeae plasmids can mediate high-level antimicrobial resistance (AMR). Using genomic and phylogenetic analyses, we show that plasmids are widespread in a collection of 3724 gonococcal isolates from 56 countries, and characterized the conjugative, β-lactamase and cryptic plasmids. We found that variants of the conjugative plasmid (which can mediate tetracycline resistance) and the β-lactamase plasmid expressing TEM-135 are associated with distinct gonococcal lineages. Furthermore, AMR plasmids are significantly more prevalent in gonococci from less wealthy countries, highlighting the need for further studies. More than 94% of gonococci possess the cryptic plasmid, with its absence correlated with the presence of a novel chromosomal type IV secretion system. Our results reveal the extent of plasmid-mediated AMR in the gonococcus, particularly in less wealthy countries, where diagnostic and therapeutic options can be limited, and highlight the risk of their global spread.

中文翻译:

淋病奈瑟氏菌质粒与不同谱系的联系及其起源国的经济地位

质粒是细菌之间水平基因转移的媒介,在淋病奈瑟氏球菌中,质粒可以介导高水平的抗药性(AMR)。使用基因组和系统发育分析,我们显示该质粒广泛分布于来自56个国家的3724淋球菌分离株中,并表征了共轭,β-内酰胺酶和隐性质粒。我们发现,接合质粒(可以介导四环素抗性)的变体和表达TEM-135的β-内酰胺酶质粒与不同的淋球菌谱系相关。此外,AMR质粒在来自较不富裕国家的淋球菌中更为普遍,这凸显了进一步研究的必要性。超过94%的淋球菌拥有隐性质粒,其缺失与新型IV型染色体分泌系统的存在有关。
更新日期:2020-03-12
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