Glycine receptors (GlyRs) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. A large number of chemically diverse compounds that are able to modulate GlyR function both positively and negatively have been reported, which provides useful information for the development of pharmacological strategies and models for the allosteric modulation of these ion channels.

中文翻译：

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甘氨酸受体变构配体库（GRALL）。

甘氨酸受体（GlyRs）介导大脑中快速抑制性神经传递，并已被公认为是疼痛的关键药理靶标。已经报道了许多能够正向和负向调节GlyR功能的化学多样性的化合物，这为开发这些离子通道的变构调节的药理策略和模型提供了有用的信息。