Abstract

An efficient and simple method for the synthesis of xanthene derivatives by using iron oxide nanoparticles (NPs) as a catalyst has been investigated. Synthesis of 9-substituted xanthene-1,8-dione derivatives involves one-pot reaction of dimedone and aldehyde in the presence of iron oxide nanoparticles using polar protic ethanol as a solvent. Interestingly, this catalyst has been recovered by simple filtration and reused for up to five cycles without much loss of its productivity. The merits of this protocol are cost-effectiveness of the catalyst, having no harmful side products, simple process, short reaction time, convenient product isolation and potential yields.

Graphic abstract

中文翻译：

---

一种高效的多相氧化铁纳米粒子催化剂，用于合成9-取代的x吨-1,8-二酮

摘要

已经研究了通过使用氧化铁纳米颗粒（NPs）作为催化剂来合成an吨衍生物的有效而简单的方法。9-取代的x吨-1,8-二酮衍生物的合成涉及在氧化铁纳米粒子存在下，使用质子惰性的乙醇作为溶剂的二甲酮与醛的一锅反应。有趣的是，该催化剂已经通过简单的过滤进行了回收，并且可以重复使用多达五个循环而不会损失很多生产率。该方案的优点是催化剂的成本效益高，无有害副产物，工艺简单，反应时间短，产物分离方便和潜在的产率。

图形摘要