PURPOSE After any procedure through the percutaneous gastrostomy (PG), a PG tube should be kept in place until a mature tract develops. For this period of maturation which takes about 2 to 4 weeks, tube dislodgement, leakage, or peritonitis can occur. Complications from PG tube maintenance can be prevented by closing the PG immediately after the procedure. The purpose of this study was to evaluate the feasibility and safety of immediate PG closure using Perclose ProGlide. MATERIALS AND METHODS A 2-week survival study was performed in a swine model. We applied one Perclose ProGlide device for closing a 13-Fr PG (n = 3) and two devices for closing a 20-Fr PG (n = 3). Body weight, temperature and laboratory findings were observed. Autopsy and microscopic examination were performed after 2 weeks. RESULTS All the swine subjects did not demonstrate any sign of systemic inflammatory responses in terms of fever and laboratory findings. From autopsy results, five pigs showed complete healing of the PG. One pig that underwent 20-Fr gastrostomy site closure with double Perclose ProGlide had scanty semitransparent fluid in the peritoneal cavity but that was not indicative of inflammation. En bloc tissue samples from all the pigs demonstrated complete wound healing of the PG sites. CONCLUSION Percutaneous application of single or double Perclose ProGlide devices is feasible and safe for the PG closure in a swine model. LEVEL OF EVIDENCE No level of evidence, Animal study.

中文翻译：

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在猪模型中使用缝合介导的血管闭合装置经皮闭合胃造口术。

目的在进行经皮胃造口术（PG）的任何手术后，应将PG管保持在原位，直到发育成熟。在大约2至4周的这段成熟期间，可能会发生管移位，渗漏或腹膜炎。可以通过在手术后立即关闭PG来防止PG管维护带来的并发症。这项研究的目的是评估使用Perclose ProGlide立即关闭PG的可行性和安全性。材料与方法在猪模型中进行了为期2周的生存研究。我们应用了一个Perclose ProGlide设备来关闭13-Fr PG（n = 3），并应用了两个设备来关闭20-Fr PG（n = 3）。观察体重，温度和实验室检查结果。2周后进行尸检和显微镜检查。结果所有猪受试者在发烧和实验室检查方面均未表现出任何全身性炎症反应迹象。从尸检结果来看，五头猪显示出PG的完全愈合。一头猪用双重Perclose ProGlide进行20-Fr胃造口术部位封闭时，腹膜腔内的半透明液体很少，但这并不表示炎症。来自所有猪的整体组织样品显示出PG位点的完全伤口愈合。结论对于猪模型中的PG封闭，经皮应用单个或两个Perclose ProGlide装置是可行且安全的。证据级别无证据级别，动物研究。一头猪用双重Perclose ProGlide进行20-Fr胃造口术部位封闭时，腹膜腔内的半透明液体很少，但这并不表示炎症。来自所有猪的整体组织样品显示出PG位点的完全伤口愈合。结论对于猪模型中的PG封闭，经皮应用单个或两个Perclose ProGlide装置是可行且安全的。证据级别无证据级别，动物研究。一头猪用双重Perclose ProGlide进行20-Fr胃造口术部位封闭时，腹膜腔内的半透明液体很少，但这并不表示炎症。来自所有猪的整体组织样品显示出PG位点的完全伤口愈合。结论对于猪模型中的PG封闭，经皮应用单个或两个Perclose ProGlide装置是可行且安全的。证据级别无证据级别，动物研究。结论对于猪模型中的PG封闭，经皮应用单个或两个Perclose ProGlide装置是可行且安全的。证据级别无证据级别，动物研究。结论对于猪模型中的PG封闭，经皮应用单个或两个Perclose ProGlide装置是可行且安全的。证据级别无证据级别，动物研究。