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Addressing Challenges in the Ultrafiltration of Biomolecules from Complex Aqueous Environments
Current Opinion in Colloid & Interface Science ( IF 8.9 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.cocis.2020.03.003
Emre Bukusoglu , Harun Koku , Pınar Zeynep Çulfaz-Emecen

Substantial progress has been made in ultrafiltration processes towards the separation of colloidal species from aqueous environments. Studies especially in the past decades have advanced the separations using functional, nanostructured membrane materials, and a thorough understanding of colloid-membrane and colloid-colloid interactions in aqueous media. In this context, this review describes the recent advances in ultrafiltration of biomolecular species, most specifically proteins, from complex environments involving a range of molecular species, ionic, non-ionic substances with varying concentrations. Ongoing efforts hint that the complexity of the interactions plays a critical role in the success of the ultrafiltration process that requires system-specific investigation of the ultrafiltration process and process parameters.



中文翻译:

应对复杂水环境中生物分子的超滤挑战

在从水环境中分离胶体物种的超滤过程中已经取得了实质性进展。尤其是在过去的几十年中,研究已经使用功能化的纳米结构膜材料进行了分离,并对水介质中的胶体-膜和胶体-胶体相互作用有了透彻的了解。在此背景下,本综述描述了从复杂环境中生物分子物种(特别是蛋白质)超滤的最新进展,该复杂环境涉及一系列分子物种,不同浓度的离子,非离子物质。正在进行的努力表明,相互作用的复杂性在超滤过程的成功中起着至关重要的作用,这需要对超滤过程和过程参数进行系统特定的研究。

更新日期:2020-03-12
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