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MicroRNAs expressed by human cytomegalovirus.
Virology Journal ( IF 4.8 ) Pub Date : 2020-03-12 , DOI: 10.1186/s12985-020-1296-4
Lichen Zhang 1 , Jiaqi Yu 1 , Zhijun Liu 2
Affiliation  

MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in length, which play an important role in gene regulation of both eukaryotes and viruses. They can promote RNA cleavage and repress translation via base-pairing with complementary sequences within mRNA molecules. Human cytomegalovirus (HCMV) encodes a large number of miRNAs that regulate transcriptions of both host cells and themselves to favor viral infection and inhibit the host’s immune response. To date, ~ 26 mature HCMV miRNAs have been identified. Nevertheless, their roles in viral infection are ambiguous, and the mechanisms have not been fully revealed. Therefore, we discuss the methods used in HCMV miRNA research and summarize the important roles of HCMV miRNAs and their potential mechanisms in infection. To study the miRNAs encoded by viruses and their roles in viral replication, expression, and infection will not only contribute to the planning of effective antiviral therapies, but also provide new molecular targets for the development of antiviral drugs.

中文翻译:

人类巨细胞病毒表达的MicroRNA。

微小RNA(miRNA)是长度约为22个核苷酸的小型非编码RNA,在真核生物和病毒的基因调控中起着重要作用。它们可以通过与mRNA分子内的互补序列进行碱基配对来促进RNA裂解并抑制翻译。人类巨细胞病毒(HCMV)编码大量的miRNA,它们调节宿主细胞及其自身的转录,从而有利于病毒感染并抑制宿主的免疫反应。迄今为止,已鉴定出约26种成熟的HCMV miRNA。然而,它们在病毒感染中的作用是模棱两可的,其机理尚未完全揭示。因此,我们讨论了用于HCMV miRNA研究的方法,并总结了HCMV miRNA的重要作用及其在感染中的潜在机制。
更新日期:2020-04-22
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