Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.

中文翻译：

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Fetuin-a在小鼠和人类脂肪组织中的表达谱

Fetuin-A（Fet-A）是最早与代谢性疾病有关的肝因子之一。Fet-A也被认为是脂肪因子，但其在脂肪组织中的表达仍值得商bat。在这里，我们比较了人和小鼠脂肪组织活检之间以及人皮下组织和内脏脂肪组织原代细胞以及小鼠3 T3-L1细胞在不同分化阶段之间Fet-A的表达。Fet-A在小鼠活检和细胞中表达，但在人活检和细胞中不表达，除了分化后的内脏脂肪组织原代细胞。尽管Fet-A在人内脏脂肪组织中的边缘表达，但Fet-A在人脂肪组织中的表达对全身Fet-A水平的主要贡献被抵消了，但它可能表明内脏脂肪组织中有特定的局部Fet-A作用。