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A retrospective analysis of the microbiology of diabetic foot infections at a Scottish tertiary hospital.
BMC Infectious Diseases ( IF 3.7 ) Pub Date : 2020-03-12 , DOI: 10.1186/s12879-020-4923-1
Katherine E Macdonald 1 , Crispin Y Jordan 2 , Emma Crichton 3 , Judith E Barnes 3 , Gillian E Harkin 3 , Lesley M L Hall 3 , Joshua D Jones 1, 4
Affiliation  

This study represents the first Scottish retrospective analysis of the microbiology of diabetic foot infections (DFIs). The aims were to compare the microbiological profile of DFIs treated at a Scottish tertiary hospital to that in the literature, gather data regarding antimicrobial resistance and investigate potential trends between the microbiological results and nature or site of the clinical sample taken and age or gender of the patients. A retrospective analysis of wound microbiology results was performed, data were obtained from one multidisciplinary outpatient foot clinic during the 12 months of the year 2017. Seventy-three patients and 200 microbiological investigations were included. In cases of soft tissue infection, the deepest part of a cleansed and debrided wound was sampled. In cases of osteomyelitis a bone biopsy was obtained. Factors influencing the pattern of microbial growth or prevalence of Staphylococcus aureus were investigated. Of the 200 microbiological investigations, 62% were culture positive, of which 37.9% were polymicrobial and 62.1% monomicrobial. Among the monomicrobial results (n = 77), most were Gram positive isolates (96.1%) and the most frequently isolated bacteria was S. aureus (84.4%). No methicillin-resistant S. aureus was reported. The prevalence of S. aureus in DFIs was associated with increasing age (p = 0.021), but no evidence of association with gender, anatomical sample site or sample material was found. The microbiological profile of DFIs in Scotland resembles that reported elsewhere in the UK. In this context, Gram positive organisms, primarily S. aureus, are most frequently isolated from DFIs. The S. aureus isolates identified were largely susceptible to antibiotic therapy. An association between increasing patient age and the prevalence of S. aureus in DFIs was observed.

中文翻译:

苏格兰三级医院对糖尿病足感染微生物学的回顾性分析。

这项研究代表了苏格兰人首次对糖尿病足感染(DFI)的微生物学进行回顾性分析。目的是比较在苏格兰三级医院治疗的DFIs的微生物学特征与文献中的DFIs的微生物学特征,收集有关抗菌素耐药性的数据,并研究微生物学结果与临床样本的性质或部位以及所用年龄或性别之间的潜在趋势。耐心。对伤口微生物学结果进行了回顾性分析,数据来自2017年12个月的一家多学科门诊足部诊所。其中包括73例患者和200项微生物学调查。在软组织感染的情况下,对清洁和清创伤口的最深部分进行采样。在骨髓炎的情况下,进行了骨活检。研究了影响微生物生长方式或金黄色葡萄球菌流行的因素。在200项微生物学调查中,培养阳性的占62%,其中微生物占37.9%,单微生物占62.1%。在单微生物结果中(n = 77),大多数是革兰氏阳性菌(96.1%),最常见的细菌是金黄色葡萄球菌(84.4%)。没有耐甲氧西林金黄色葡萄球菌的报道。金黄色葡萄球菌在DFI中的患病率与年龄的增长有关(p = 0.021),但没有发现与性别,解剖学样本部位或样本材料有关的证据。苏格兰DFI的微生物学特征与英国其他地方的报道相似。在这种情况下,革兰氏阳性生物,主要是金黄色葡萄球菌,最常从DFI中分离出来。S. 鉴定出的金黄色葡萄球菌在很大程度上易受抗生素治疗。观察到患者年龄的增长与DFI中金黄色葡萄球菌的患病率之间存在关联。
更新日期:2020-03-12
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