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Identification of immune cells and mRNA associated with prognosis of gastric cancer
BMC Cancer ( IF 3.8 ) Pub Date : 2020-03-12 , DOI: 10.1186/s12885-020-6702-1
Mingming Wang , Zedong Li , Yu Peng , Jianyu Fang , Tao Fang , Jiajia Wu , Jun Zhou

The clinical success demonstrates the enormous potential of immunotherapy in cancer treatment. This article presented research linking gastric cancer to immune cells, based on RNA-seq data of Stomach adenocarcinoma (STAD) and gene expression profile of GSE84437, 24 kinds of tumor-infiltrating immune cells were quantified by single-sample gene set enrichment analysis. Th2 cells, T helper cells, and Mast cells were identified as prognostic immune cells in both TCGA and GEO groups. Then SUPV3L1 and SLC22A17 were identified as hub genes which may affect immune cell infiltration by correlation analysis. Survival analysis further proved that hub genes and prognostic immune cells are associated with the prognosis of gastric cancer. In gastrointestinal tumors, hub genes and prognostic immune cells also found differences in non-tumor and tumor tissues. We found that three immune cells infiltration are associated with the prognosis of gastric cancer and further identify two hub genes. These two key genes may affect immune cell infiltration, result in the different prognosis of patients.

中文翻译:

鉴定与胃癌预后相关的免疫细胞和mRNA

临床成功证明了免疫疗法在癌症治疗中的巨大潜力。本文基于胃腺癌(STAD)的RNA-seq数据和GSE84437的基因表达谱,提出了将胃癌与免疫细胞联系起来的研究,通过单样本基因集富集分析定量了24种肿瘤浸润免疫细胞。在TCGA和GEO组中,Th2细胞,T辅助细胞和肥大细胞均被鉴定为预后免疫细胞。然后通过相关分析将SUPV3L1和SLC22A17鉴定为可能影响免疫细胞浸润的中枢基因。生存分析进一步证明,毂基因和预后免疫细胞与胃癌的预后有关。在胃肠道肿瘤中,中枢基因和预后免疫细胞也在非肿瘤组织和肿瘤组织中发现差异。我们发现三种免疫细胞浸润与胃癌的预后有关,并进一步确定了两个中心基因。这两个关键基因可能影响免疫细胞浸润,导致患者预后不同。
更新日期:2020-03-12
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