The E phosphine ligands (R = Ph, o-Tol, Cy), abbreviated as RPEWO-F₄, are stable in solution, but they develop a rich reactivity on coordination to PdCl₂. The chelate P-olefin coordination to PdCl₂ leads eventually to a Z conformation of the fluorinated-chalcone group o-C₆F₄CH═CHC(O)Ph. From there, a cyclization reaction occurs involving the C═O group and activation of a F atom, yielding a strongly chelated PdCl₂(P-carbene) complex. The carbene carbon atom in the complex displays some electrophilicity, which is expressed in hydrolysis, ammonolysis, and oxidation (with peroxide) reactions, affording PdCl₂ complexes with new P,C,O-pincer, P,C,N-pincer, or P,O-chelate fluorinated ligands. The C–F activation reactions are slow in comparison to the catalysis rates when the [PdCl₂(RPEWO-F₄)] complexes have been used in Negishi catalyses. Consequently, the reactivity discussed here is not expected to interfere with the interpretation of the data obtained in Pd-catalytic studies or processes, at least for fast transmetalating nucleophiles.

中文翻译：

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氟化活化查尔酮膦RPEWO-F _4的反应性，该活化是由CF活化后与PdCl _{2配位引起的}

所述ë膦配体（R = PH，Õ -Tol中，Cy），缩写为RPEWO-F ₄，是在溶液中稳定，但他们开发上协调丰富的反应性的PdCl ₂。螯合的P-烯烃与PdCl _2的配位最终导致氟化查尔酮基o -C ₆ F ₄ CH = CHC（O）Ph的Z构象。从那里开始发生涉及C═O基团和F原子活化的环化反应，生成强螯合的PdCl ₂（P-卡宾）络合物。络合物中的卡宾碳原子显示出一定的亲电性，这表现为水解，氨解和氧化（具有过氧化物）反应，从而提供了具有新的P，C，O钳，P，C，N钳或PdCl _2的络合物。 P，O-螯合物氟化配体。与[PdCl ₂（RPEWO-F ₄）]络合物用于Negishi催化剂相比，CF活化反应的催化速率慢。因此，至少在快速重金属化亲核试剂方面，预期此处讨论的反应性不会干扰在Pd催化研究或过程中获得的数据的解释。