Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12.

中文翻译：

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Chaetomium nigricolor的抗炎代谢物。

从黑毛龟（Chaetomium nigricolor）的培养基中获得了十二种代谢物，包括新的呋喃衍生物，甲基琥珀酰Sumiki's酸（1）和先前报道的双萘-γ-吡喃酮的两个新的阻转异构体（aS）-asperpyrone A和（ aS）-甲孕酮A（2和3）。通过光谱学，化学和按摩技术阐明了结构。化合物2和3抑制了脂多糖刺激的RAW 264.7巨噬细胞中一氧化氮的产生。发现化合物2可抑制核因子-κB和c-Jun N端激酶的活化，进而抑制促炎性介质和细胞因子，包括一氧化氮，前列腺素E2，白介素（IL）-1β，肿瘤坏死因子-α， IL-6和IL-12。