We propose a new method to large-scale synthesize polymeric colloidal dimers by electrostatically-mediated intramolecular cross-linking of an example di-block copolymer of poly(isoprene)-b-poly(vinylpyridine) (PI-b-P4VP) in highly concentrated solutions. The synthesis is orthogonally performed in a highly polar solvent such as DMSO. The first colloid is achieved by intramolecular cross-linking of the PI block with 1,6-hexanediisothiocyanate after modification with 2-mercaptoethylamine hydrochloride to introduce an electrostatic interaction. The Janus single-chain nanoparticle of cPI-P4VP is derived. In the sequential step, the other colloid is achieved by intramolecular cross-linking the P4VP block of cPI-P4VP with 1,5-diiodopentane after modification with iodoethane. The polymer colloidal dimer of cPI-cP4VP is thus achieved. The Janus cPI-cP4VP dimer is composed of two different domains: the cPI containing residual amine and cyanate groups and the cP4VP containing residual pyridine and quaternized groups. The dimer can be synthesized at a higher concentration of 100 mg/mL. A huge family of functional colloidal dimers is expected after selectively loading materials within the desired colloidal domains.

中文翻译：

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浓缩溶液中分子内交联的Janus胶体二聚体

我们提出了一种通过静电介导的高浓度聚（异戊二烯）-b-聚（乙烯基吡啶）（PI- b- P4VP）的示例性二嵌段共聚物的分子内交联大规模合成聚合物胶体二聚体的新方法解决方案。合成是在高极性溶剂（例如DMSO）中正交进行的。通过用2-巯基乙胺盐酸盐改性以引入静电相互作用之后，通过将PI嵌段与1，6-己二异硫氰酸酯进行分子内交联来获得第一胶体。衍生出c PI-P4VP的Janus单链纳米颗粒。在后续步骤中，另一种胶体是通过分子内交联c用碘乙烷改性后的带有1,5-二碘戊烷的PI-P4VP。因此获得了c PI- c P4VP的聚合物胶体二聚体。Janus c PI- c P4VP二聚体由两个不同的域组成：包含残留胺和氰酸酯基团的c PI和包含残留吡啶和季铵化基团的c P4VP。可以以更高的100 mg / mL浓度合成二聚体。在选择性地将材料加载到所需的胶体结构域内后，预计会有功能性胶体二聚体的巨大家族。