The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome‐wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.

中文翻译：

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神经干细胞在皮质发育过程中获得神经胶质身份的表观遗传调控。

神经系统由数百个神经元亚型和神经胶质细胞组成，它们显示出特定的基因表达，并由共同祖先神经干细胞 (NSC) 产生。随着分析表观遗传学和染色质结构的实验技术和分子工具的迅速发展，发育中的神经干细胞中 DNA 甲基化、组蛋白修饰和染色质可及性的综合事件和全基因组状态正逐渐被揭示。在这里，我们回顾了阐明表观遗传和染色质调控在 NSC 中的作用的最新进展，特别关注神经胶质身份的获得以及表观遗传调控如何在小鼠皮质发育过程中实现 NSC 的时间调控。