Ankylosing spondylitis (AS ) is a common spondyloarthropathy primarily affecting the axial skeleton and strongly associated with HLA –B*27 carriage. Genetic evidence implicates both autoinflammatory processes and autoimmunity against an HLA –B*27 –restricted autoantigen in immunopathology. In addition to articular symptoms, up to 70% of AS patients present with concurrent bowel inflammation, suggesting that adverse interactions between a genetically primed host immune system and the gut microbiome contribute to the disease. Accordingly, this study aimed to characterize adaptive immune responses to antigenic stimuli in AS .

中文翻译：

---

强直性脊柱炎患者的T细胞受体免疫测序揭示了改变的库多样性和疾病相关的克隆扩展。

强直性脊柱炎（AS）是一种常见的脊椎关节病，主要影响轴向骨骼，并与HLA –B * 27转运密切相关。遗传证据暗示免疫病理学中针对HLA –B * 27 –限制性自身抗原的自身炎症过程和自身免疫。除关节症状外，多达70％的AS患者还出现并发肠炎，这表明遗传引发的宿主免疫系统与肠道微生物组之间的不良相互作用也导致了该疾病。因此，该研究旨在表征对AS中抗原刺激的适应性免疫应答。