Microcrystalline cellulose pellets for oral drug delivery are often produced by a combined wet extrusion‐spheronization process. During the entire process, the cylindrical as well as the spherical pellets are exposed to various stresses resulting in a change of their shape and size due to plastic deformation and breakage. In this work, the effect of moisture content of pellets on their mechanical behavior is studied. In static compression tests, the strong influence of water content on deformation behavior of pellets is confirmed. Moreover, impact tests are performed using a setup consisting of three high‐speed cameras to record pellet‐wall collisions. Material properties, such as stiffness, restitution coefficient, breakage force, and displacement, were analyzed depending on the water content.

中文翻译：

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微晶纤维素颗粒的接触行为取决于其含水量

用于口服药物递送的微晶纤维素颗粒通常是通过湿法挤出-滚圆法组合工艺生产的。在整个过程中，圆柱形和球形粒料都会受到各种应力的作用，由于塑性变形和破裂而导致其形状和尺寸发生变化。在这项工作中，研究了颗粒的水分含量对其机械性能的影响。在静态压缩试验中，证实了含水量对粒料变形行为的强烈影响。此外，冲击试验是使用由三个高速摄像机组成的装置进行的，以记录丸粒壁碰撞。根据含水量分析了材料特性，例如刚度，恢复系数，断裂力和位移。