Abstract

Purpose

The purpose of this study was to compare dynamic ¹⁸F-FGln PET/CT images of healthy subjects and cancer patients and explore the best imaging phase for different cancers.

Methods

Thirteen healthy volunteers and 31 cancer patients separately underwent ¹⁸F-FGln and ¹⁸F-FDG PET/CT scans within 1 week. The distributions of ¹⁸F-FGln and ¹⁸F-FDG in the whole body and the tumor avidity were analyzed and compared. The tumor maximum standardized uptake values (SUVmax) and tumor-to-nontumor SUV ratio (SUR) of ¹⁸F-FGln/PET at different scan phases were compared.

Results

Compared to the healthy subjects, the cancer patients had lower ¹⁸F-FGln activity (SUVmean) in most normal organs, especially in the lung, muscle, spleen, and heart (p < 0.05). Additionally, the FGln-avid tumors did not necessarily manifest as FDG-avid and vice versa. Overall, among the 31 primary malignant lesions confirmed by biopsy or postoperative pathological analysis, 29 showed increased radioactive uptake on all ¹⁸F-FGln PET/CT imaging phases. The peak of SUVmax in breast and thyroid cancers was within 10 min, while in lung cancers, the plateau of SUVmax was within 30 min to 60 min. The SURs of lung cancer (p = 0.046) and thyroid cancer (p = 0.794) increased from the early-phase to the late-phase acquisition; however, a significant decrease was observed in the breast lesions (p = 0.022).

Conclusions

¹⁸F-FGln images may further supplement the diagnostic ability of ¹⁸F-FDG in cancer patients and detect metabolic changes in different tumors. Furthermore, the imaging time for ¹⁸F-FGln PET/CT needs to be optimized for different cancer types to improve the contrast resolution of tumors.

中文翻译：

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健康志愿者和肿瘤患者中18F-（2S，4R）4-氟谷氨酰胺的动态PET / CT成像。

摘要

目的

这项研究的目的是比较健康受试者和癌症患者的动态¹⁸ F-FGln PET / CT图像，并探索针对不同癌症的最佳成像阶段。

方法

13名健康志愿者和31名癌症患者在1周内分别进行了¹⁸ F-FGln和¹⁸ F-FDG PET / CT扫描。分析并比较了¹⁸ F-FGln和¹⁸ F-FDG在全身的分布以及肿瘤的亲和力。比较了在不同扫描阶段的¹⁸ F-FGln / PET的肿瘤最大标准化摄取值（SUVmax）和肿瘤与非肿瘤SUV比（SUR）。

结果

相较于健康受试者，所述癌症患者具有较低的¹⁸在大多数正常器官F-FGln活性（SUVmean），尤其是在肺，肌肉，脾，和心脏（p  <0.05）。另外，FGln-avid肿瘤不一定表现为FDG-avid，反之亦然。总体而言，在活检或术后病理分析证实的31例原发性恶性病变中，有29例在^18个F-FGln PET / CT成像阶段均显示出放射性摄取增加。乳腺癌和甲状腺癌中SUVmax的峰值在10分钟内，而在肺癌中，SUVmax的平稳期在30分钟至60分钟内。肺癌（p  = 0.046）和甲状腺癌（p = 0.794）从早期采集增加到了后期采集；然而，在乳腺病变中观察到显着减少（p  = 0.022）。

结论

¹⁸ F-FGln图像可以进一步补充¹⁸ F-FDG在癌症患者中的诊断能力，并检测不同肿瘤中的代谢变化。此外，需要针对不同癌症类型优化¹⁸ F-FGln PET / CT的成像时间，以提高肿瘤的对比分辨率。