Abstract

Therapeutic drug monitoring is used in the clinical setting in the optimisation of dosages to overcome inter-patient pharmacokinetic variability, increasing efficacy whilst reducing toxicity. Imatinib is a tyrosine kinase inhibitor, displaying large variations in plasma concentrations that impact therapeutic success. As a result, imatinib has been the focus in the development of innovative techniques, aimed at its quantification in plasma. Liquid chromatography coupled with tandem mass spectrometry is currently the gold standard; however, cost and availability of the equipment limit its wider application in clinical settings. Recent advances in the field have shown Raman spectroscopy and electrochemistry to be key techniques for the development of promising analytical tools. This article reviews the latest advances towards less costly, more portable solutions that can be used at the point of care.

Graphical abstract

中文翻译：

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迈向用于伊马替尼治疗药物监测的护理点系统。

摘要

治疗药物监测用于临床环境中的剂量优化，以克服患者间药代动力学差异，提高疗效同时降低毒性。伊马替尼是一种酪氨酸激酶抑制剂，显示出影响治疗成功的血浆浓度变化很大。因此，伊马替尼一直是创新技术开发的重点，旨在对其在血浆中进行量化。液相色谱与串联质谱联用是目前的金标准；然而，该设备的成本和可用性限制了其在临床环境中的更广泛应用。该领域的最新进展表明，拉曼光谱和电化学是开发有前景的分析工具的关键技术。本文回顾了降低成本的最新进展，