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Oxidative stress assessment in sickle cell anemia patients treated with hydroxyurea.
Annals of Hematology ( IF 3.5 ) Pub Date : 2020-03-12 , DOI: 10.1007/s00277-020-03987-7
Cristiane O Renó 1 , Amanda Rodrigues Barbosa 2 , Sara Santos de Carvalho 2 , Melina B Pinheiro 3 , Danyelle Romana Rios 2 , Vanessa F Cortes 1 , Leandro A Barbosa 1 , Hérica L Santos 1
Affiliation  

Hydroxyurea (HU) is used as a therapy in sickle cell anemia (SCA). Many studies have established that HU improves patient quality of life by reducing symptoms. However, the effect of HU on erythrocytes is not well-described. We evaluated several parameters related to oxidative stress and total lipid content of erythrocytes in patients with SCA. The patient cohort consisted of 7 SCA patients treated with HU, 17 untreated SCA patients, and 15 healthy subjects. Erythrocytes from patients with SCA displayed increased oxidative stress relative to the control group, including higher thiobarbituric acid reactive substances (TBARS), Fe3+ content, and osmotic fragility, and decreased total cholesterol. We observed that treatment of SCA patients with HU increased Fe3+ content and activity of glutathione peroxidase, and decreased glutathione reductase activity, glutathione levels, total cholesterol, and phospholipid content comaperaded to patients untreated with HU. Thus, HU alters biochemical characteristics of erythrocytes; future studies will determine whether they are beneficial or not.

中文翻译:

用羟基脲治疗镰状细胞性贫血患者的氧化应激评估。

羟基脲(HU)被用作镰状细胞性贫血(SCA)的治疗方法。许多研究已经证实,HU通过减轻症状改善了患者的生活质量。但是,HU对红细胞的作用尚未充分描述。我们评估了与SCA患者中氧化应激和红细胞总脂质含量有关的几个参数。该患者队列由接受过HU治疗的7位SCA患者,17位未经治疗的SCA患者和15位健康受试者组成。相对于对照组,来自SCA患者的红细胞显示出更高的氧化应激,包括更高的硫代巴比妥酸反应性物质(TBARS),Fe3 +含量和渗透压脆性,以及总胆固醇降低。我们观察到,用HU治疗SCA患者可增加Fe3 +含量和谷胱甘肽过氧化物酶活性,对于未经HU治疗的患者,谷胱甘肽还原酶活性,谷胱甘肽水平,总胆固醇和磷脂含量降低。因此,HU改变了红细胞的生化特性。未来的研究将确定它们是否有益。
更新日期:2020-03-12
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