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Improved drug delivery and anti-tumor efficacy of combinatorial liposomal formulation of genistein and plumbagin by targeting Glut1 and Akt3 proteins in mice bearing prostate tumor.
Colloids and Surfaces B: Biointerfaces ( IF 5.8 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.colsurfb.2020.110966
Yuan-Yuan Song 1 , Ye Yuan 1 , Xu Shi 1 , Yuan-Yuan Che 1
Affiliation  

Despite the plethora of significant research progress made to develop novel strategies for the treatment of prostate cancer, this disease remains one of the major global health challenges among men. However, using a co-treatment approach utilizing two or more anticancer drugs has shown tremendous success in the treatment of many cancer types. Nanoliposomes are well known to encapsulate multiple drugs and deliver them at the desired site. In this work, we report the synthesis of nanoliposomes (∼100 nm) encapsulating two drugs, plumbagin, and genistein, to synergistically inhibit the growth of prostate cancer cells. The combination of plumbagin and genistein drugs was found inhibiting xenograft prostate tumor growth by ∼80 % without any appreciable toxicity. Mechanistically, the combination of plumbagin and genistein containing nanoliposomes leads to the inhibition of PI3K/AKT3 signaling pathway as well as the decreased population of Glut-1 transporters to impart the retardation in tumor growth. Decrease in proliferative cells and blood vessels are early biological processes that laid the foundation of the observed anti-tumor effect. Thus, a novel, and non-toxic liposomal formulation, containing plumbagin and genistein drugs, is reported, which can deliver anticancer agents to prostate tumors and inhibit the growth.

中文翻译:

通过靶向Glut1和Akt3蛋白在患有前列腺肿瘤的小鼠中,可实现染料木黄酮和铅蛋白的脂质体组合制剂的改善的药物传递和抗肿瘤功效。

尽管开发了用于治疗前列腺癌的新策略的大量研究取得了很大进展,但是该疾病仍然是男性中主要的全球健康挑战之一。但是,使用两种或多种抗癌药物的联合治疗方法已显示出在许多癌症类型中的巨大成功。众所周知,纳米脂质体可包裹多种药物并将其递送至所需部位。在这项工作中,我们报告了纳米脂质体(约100 nm)的合成,该纳米脂质体封装了两种药物,lumbagin和染料木黄酮,以协同抑制前列腺癌细胞的生长。已经发现,将李子木苷和染料木黄酮类药物联合使用可将异种移植前列腺肿瘤的生长抑制约80%,而没有任何明显的毒性。机械上,含铅肽和染料木黄酮的纳米脂质体的组合可抑制PI3K / AKT3信号通路,并减少Glut-1转运蛋白的数量,从而延缓肿瘤的生长。增殖细胞和血管的减少是早期的生物学过程,为观察到的抗肿瘤作用奠定了基础。因此,据报道,一种新的,无毒的脂质体制剂,包含plumbagin和染料木黄酮类药物,可以将抗癌剂递送至前列腺肿瘤并抑制其生长。
更新日期:2020-03-12
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