Rheumatoid arthritis is a well-known chronic inflammatory joint disorder. It encompasses systemic inflammation, autoimmunity and development of several joint abnormalities leading to the lifelong disability and increased mortality. Exosomes are nano-sized (30-100 nm) mammalian extracellular particles with essential properties to regulate biological processes and cellular signaling by transferring protein and genetic materials. Understanding the diversity in the exosomal contents and their corresponding targets may contribute to better recognition of the processes that are implicated in the development and progression of diseases such as autoimmune disorders. Exosomes may act as a potential biomarker for the diagnosis of autoimmune disorders. In the present review, we aimed to bring together the relevant evidence on the biology of exosomes in rheumatoid arthritis, and also discuss the recent findings regarding the diagnostic, prognostic and therapeutic promise of these nanoparticles.

中文翻译：

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外泌体：类风湿关节炎的有效参与者。

类风湿关节炎是一种众所周知的慢性炎症性关节疾病。它包括全身性炎症，自身免疫和几种关节异常的发展，导致终身残疾和死亡率增加。外泌体是具有必要特性的纳米级（30-100 nm）哺乳动物细胞外颗粒，可通过转移蛋白质和遗传物质来调节生物过程和细胞信号传导。了解外泌体内容物及其相应靶标的多样性可能有助于更好地认识与疾病（例如自身免疫性疾病）的发生和发展有关的过程。外来体可以作为诊断自身免疫性疾病的潜在生物标志物。在目前的评论中，