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Long non-coding RNAs regulate drug resistance in cancer
Molecular Cancer ( IF 37.3 ) Pub Date : 2020-03-12 , DOI: 10.1186/s12943-020-01162-0
Kaisheng Liu , Lin Gao , Xiaoshi Ma , Juan-Juan Huang , Juan Chen , Leli Zeng , Charles R. Ashby , Chang Zou , Zhe-Sheng Chen

Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.

中文翻译:

长的非编码RNA调节癌症的耐药性

化学抗性,无论是固有的还是获得性的,都是治疗癌症的主要障碍。癌细胞对化学治疗药物的抗药性可能来自多种机制。在过去的十年中,已有报道称1ong非编码RNA(lncRNA)可以介导癌细胞的致癌性和耐药性/敏感性。本文详细回顾了有关lncRNA在介导耐药性中作用的最新研究。
更新日期:2020-04-22
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