Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN. A total of 133,698 adults were included for the current analysis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) were calculated. The logistic regression was used to explore the association of the four markers with the presence and size of TN. The prevalence of TN was 55.1% among females and 44% among males; 13% of women and 8% of men had non-micronodule. In women, MHR and PLR were significantly associated with the presence of TN and non-micronodule; in men, MHR and NLR were significantly associated with the presence of TN and non-micronodule. As a low-cost, simple, and reproducible inflammatory marker, MHR is strongly associated with the presence and size of TN irrespective of the gender.

中文翻译：

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单核细胞与高密度脂蛋白胆固醇之比与甲状腺结节的存在和大小有关，而与性别无关

全身性炎症可能与甲状腺结节（TN）的形成和发展有关。这项大规模研究的目的是研究几种简单的炎症标记物与TN的存在和大小的关系。总共133,698名成人包括在本分析中。计算中性粒细胞与淋巴细胞之比（NLR），血小板与淋巴细胞之比（PLR），淋巴细胞与单核细胞之比（LMR）以及单核细胞与高密度脂蛋白胆固醇之比（MHR）。Logistic回归用于探讨四种标记物与TN的存在和大小的关联。TN的患病率在女性中为55.1％，在男性中为44％；13％的女性和8％的男性患有非小结节。在女性中，MHR和P​​LR与TN和非小结节的存在密切相关。在男人中 MHR和NLR与TN和非微结节的存在显着相关。作为一种低成本，简单且可重现的炎症标志物，MHR与TN的存在和大小密切相关，而与性别无关。