Periodontitis was reported to be associated with inflammatory bowel disease (IBD). However, the association between them has not been firmly established in the existing literature. Therefore, this meta-analysis was conducted to evaluate the relationship between periodontitis and IBD. Electronic databases were searched for publications up to August 1, 2019 to include all eligible studies. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated to determine the association between periodontal disease and IBD using a random or fixed effects model according to heterogeneity. Six eligible studies involving 599 IBD patients and 448 controls were included. The pooled OR between periodontitis and IBD was 3.17 (95% CI: 2.09–4.8) with no heterogeneity observed (I2 = 0.00%). The pooled ORs were 3.64 (95% CI: 2.33–5.67) and 5.37 (95% CI: 3.30–8.74) for the associations between periodontitis and the two sub-categories of IBD, Crohn’ s disease and ulcerative colitis, respectively. The results demonstrated that periodontitis was significantly associated with IBD. However, the mechanisms underlying periodontitis and IBD development are undetermined. Further studies are needed to elucidate this relationship.

中文翻译：

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牙周炎和炎性肠病：一项荟萃分析。

据报道，牙周炎与炎症性肠病（IBD）有关。然而，它们之间的联系在现有文献中还没有被牢固地建立。因此，本荟萃分析旨在评估牙周炎与IBD之间的关系。在电子数据库中搜索了截至2019年8月1日的出版物，以包括所有符合条件的研究。根据异质性，使用随机或固定效应模型估算合并的优势比（OR）和95％置信区间（95％CI），以确定牙周疾病与IBD之间的关联。包括599名IBD患者和448名对照的六项合格研究。牙周炎和IBD之间的合并OR为3.17（95％CI：2.09-4.8），未观察到异质性（I2 = 0.00％）。合并的OR为3.64（95％CI：2.33-5.67）和5。37（95％CI：3.30–8.74）分别与牙周炎和IBD的两个亚类，克罗恩病和溃疡性结肠炎之间的关联有关。结果表明，牙周炎与IBD显着相关。但是，牙周炎和IBD发生的机制尚不清楚。需要进一步研究以阐明这种关系。