This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of epileptiform activity by the LTM EEG recording can develop the better treatment strategy. The LTM EEG recordings of 770 individuals with a definite diagnosis of epilepsy were assessed. Two hundred sixty-two individuals accorded with the inclusion criteria and exclusion criteria. We collect the demographic and clinical information and LTM EEG data of these 262 individuals. We analysed the data by one-way analysis of variance and Cox proportional hazards models. We found that more epileptiform activity were found with LTM EEG recording than regular EEG recording in seizure-free individuals. We found several clinical factors could be associated with epileptiform activity on LTM EEG in seizure free patients by a one-way analysis: symptomatic or cryptogenic epilepsy [hazard ratio (HR) = 2.6], history of cerebral trauma (HR = 7.5), and abnormal imaging findings (HR = 3.1). The following factors suggested a correlation between history of cerebral trauma (HR = 2.4) and history of cerebral surgery (HR = 3.4) with epileptiform activity on LTM EEG presentation by multivariate logistic regression analysis. The study indicated a correlation of a number of factors with abnormal LTM EEG presentation: symptomatic or cryptogenic epilepsy, history of cerebral trauma, history of cerebral surgery, and abnormal imaging findings. The LTM EEG recording may help find epileptiform activity in high risk seizure-free individuals. The individuals need be reevaluated the therapeutic strateagies, and increase the hope to reach real seizure-free.

中文翻译：

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长期脑电图 (EEG) 在无癫痫发作人群中的临床价值：来自横断面研究的启示。

本研究旨在探讨长期脑电图（LTM EEG）在服用抗癫痫药物（AEDs）2年以上无癫痫发作个体中的临床价值。我们试图在无癫痫发作的患者中寻找与 LTM EEG 的癫痫样活动相关的临床因素。我们希望通过 LTM EEG 记录检测癫痫样活动可以制定更好的治疗策略。评估了 770 名确诊为癫痫的个体的 LTM EEG 记录。262人符合纳入标准和排除标准。我们收集这 262 人的人口统计和临床信息以及 LTM EEG 数据。我们通过单向方差分析和 Cox 比例风险模型分析数据。我们发现，在没有癫痫发作的个体中，LTM EEG 记录比常规 EEG 记录发现更多的癫痫样活动。我们通过单向分析发现几个临床因素可能与无癫痫发作患者 LTM EEG 的癫痫样活动相关：症状性或隐源性癫痫[风险比 (HR) = 2.6]、脑外伤史 (HR = 7.5) 和影像学发现异常（HR = 3.1）。通过多变量逻辑回归分析，以下因素表明脑外伤史 (HR = 2.4) 和脑手术史 (HR = 3.4) 与 LTM EEG 呈现的癫痫样活动之间存在相关性。该研究表明许多因素与异常 LTM EEG 表现相关：症状性或隐源性癫痫、脑外伤史、脑手术史、和异常的影像学发现。LTM EEG 记录可能有助于发现高危无癫痫发作个体的癫痫样活动。个人需要重新评估治疗策略，并增加实现真正无癫痫发作的希望。