The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly a lifestyle-driven disease. The Feel4Diabetes-study aimed to tackle unhealthy lifestyle (unhealthy diet, lack of physical activity, sedentary behaviour, and excess weight) of families with a child in the first grades of elementary school. These schools were located in regions with a relatively low socio-economic status in Belgium, Bulgaria, Finland, Greece, Hungary and Spain. Special attention was paid to families with a high risk of developing type 2 diabetes mellitus. The aim of this paper is to describe the detailed methodology of the intervention’s cost-effectiveness analysis. Based on the health economic evaluation of the Toybox-study, both a decision analytic part and a Markov model have been designed to assess the long-term (time horizon of 70 year with one-year cycles) intervention’s value for money. Data sources used for the calculation of health state incidences, transition probabilities between health states, health state costs, and health state utilities are listed. Intervention-related costs were collected by questionnaires and diaries, and attributed to either all families or high risk families only. The optimal use of limited resources is pivotal. The future results of the health economic evaluation of the Feel4Diabetes-study will contribute to the efficient use of those resources.

中文翻译：

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Feel4Diabetes研究的健康经济评估方法

2型糖尿病对社会的临床和经济负担正在增加。鉴于2型糖尿病主要是一种生活方式驱动的疾病，因此有效而有效的预防措施可能会阻止这种疾病的流行。Feel4Diabetes研究旨在解决小学一年级有孩子的家庭的不健康生活方式（不健康饮食，缺乏体育锻炼，久坐行为和超重）。这些学校位于比利时，保加利亚，芬兰，希腊，匈牙利和西班牙的社会经济地位相对较低的地区。特别注意那些罹患2型糖尿病的高风险家庭。本文的目的是描述干预措施成本效益分析的详细方法。根据Toybox研究的健康经济评估，设计了决策分析部分和马尔可夫模型，以评估长期（70年的时间跨度和一年的周期）干预的物有所值。列出了用于计算健康状态发生率，健康状态之间的转换概率，健康状态成本和健康状态效用的数据源。与干预有关的费用通过问卷和日记收集，并仅归因于所有家庭或高风险家庭。有限资源的最佳使用至关重要。Feel4Diabetes研究的健康经济评估的未来结果将有助于有效利用这些资源。列出了用于计算健康状态发生率，健康状态之间的转换概率，健康状态成本和健康状态效用的数据源。与干预有关的费用通过问卷和日记收集，并仅归因于所有家庭或高风险家庭。有限资源的最佳使用至关重要。Feel4Diabetes研究的健康经济评估的未来结果将有助于有效利用这些资源。列出了用于计算健康状态发生率，健康状态之间的转换概率，健康状态成本和健康状态效用的数据源。与干预有关的费用通过问卷和日记收集，并仅归因于所有家庭或高风险家庭。有限资源的最佳使用至关重要。Feel4Diabetes研究的健康经济评估的未来结果将有助于有效利用这些资源。