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Assessing left ventricular systolic function in children with a history of Kawasaki disease
BMC Cardiovascular Disorders ( IF 2.1 ) Pub Date : 2020-03-12 , DOI: 10.1186/s12872-020-01409-0
Zhou Lin , Jingjing Zheng , Weiling Chen , Tingting Ding , Wei Yu , Bei Xia

The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause of acquired heart disease in children. Previous studies have well summarized the acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE); however, changes in LV systolic function after long-term follow-up remain unclear. One hundred children with a history of KD, but without coronary artery aneurysms, were enrolled. These children were divided into two subgroups based on the presence or absence of coronary artery dilatation (CAD). The duration of follow-up was > 7 years. The control group consisted of 51 healthy children. The LV myocardial strain were measured by two- and three-dimensional STE. Two-dimensional STE not only revealed that LV longitudinal strain decreased in part of segments in both KD groups, but also showed that global strain decreased in the KD group with CAD compared to the controls (P < 0.05). Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were obtained by 3D STE. Compared to the controls, GLS and GAS decreased in both KD groups (P < 0.05). GCS and GRS decreased in the KD group with CAD, but was unchanged in the KD group without CAD (P < 0.05). LV systolic dysfunction in children with KD and CAD was more severe than KD children without CAD compared to healthy children. This dysfunction can be assessed by LV regional and global myocardial strain using two- and three-dimensional STE.

中文翻译:

评估有川崎病史的儿童的左心室收缩功能

川崎病(KD)的发病率正在增加。实际上,KD已成为儿童获得性心脏病的最常见原因。以前的研究已经使用斑点跟踪超声心动图(STE)很好地总结了急性期左心室(LV)的收缩功能障碍。然而,长期随访后左室收缩功能的变化仍不清楚。入选了一百名有KD病史但无冠状动脉瘤的儿童。根据是否存在冠状动脉扩张(CAD)将这些孩子分为两个亚组。随访时间> 7年。对照组由51名健康儿童组成。通过二维和三维STE测量左心室心肌应变。二维STE不仅显示两个KD组的部分节段的LV纵向应变均降低,而且还显示与对照组相比,CAD的KD组的整体应变降低(P <0.05)。通过3D STE获得整体纵向应变(GLS),整体圆周应变(GCS),整体径向应变(GRS)和整体面积应变(GAS)。与对照组相比,两个KD组的GLS和GAS均降低(P <0.05)。有CAD的KD组GCS和GRS下降,而没有CAD的KD组GCS和GRS保持不变(P <0.05)。与健康儿童相比,KD和CAD儿童的LV收缩功能障碍比没有CAD的KD儿童严重。可以使用二维和三维STE通过LV局部和整体心肌应变评估这种功能障碍。但也显示与对照组相比,CAD的KD组的整体应变降低了(P <0.05)。通过3D STE获得整体纵向应变(GLS),整体圆周应变(GCS),整体径向应变(GRS)和整体面积应变(GAS)。与对照组相比,两个KD组的GLS和GAS均降低(P <0.05)。有CAD的KD组GCS和GRS降低,而没有CAD的KD组GCS和GRS不变(P <0.05)。与健康儿童相比,KD和CAD儿童的LV收缩功能障碍比没有CAD的KD儿童严重。可以使用二维和三维STE通过LV区域和整体心肌应变评估这种功能障碍。但也显示,与对照组相比,KD组的CAD总体应变降低了(P <0.05)。通过3D STE获得整体纵向应变(GLS),整体圆周应变(GCS),整体径向应变(GRS)和整体面积应变(GAS)。与对照组相比,两个KD组的GLS和GAS均降低(P <0.05)。有CAD的KD组GCS和GRS降低,而没有CAD的KD组GCS和GRS不变(P <0.05)。与健康儿童相比,KD和CAD儿童的LV收缩功能障碍比没有CAD的KD儿童严重。可以使用二维和三维STE通过LV区域和整体心肌应变评估这种功能障碍。通过3D STE获得了总面积应变(GAS)。与对照组相比,两个KD组的GLS和GAS均降低(P <0.05)。有CAD的KD组GCS和GRS降低,而没有CAD的KD组GCS和GRS不变(P <0.05)。与健康儿童相比,KD和CAD儿童的LV收缩功能障碍比没有CAD的KD儿童严重。可以使用二维和三维STE通过LV区域和整体心肌应变评估这种功能障碍。通过3D STE获得了总面积应变(GAS)。与对照组相比,两个KD组的GLS和GAS均降低(P <0.05)。有CAD的KD组GCS和GRS降低,而没有CAD的KD组GCS和GRS不变(P <0.05)。与健康儿童相比,KD和CAD儿童的LV收缩功能障碍比没有CAD的KD儿童严重。可以使用二维和三维STE通过LV区域和整体心肌应变评估这种功能障碍。
更新日期:2020-03-12
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