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Expression and function of cartilage-derived pluripotent cells in joint development and repair.
Stem Cell Research & Therapy ( IF 7.5 ) Pub Date : 2020-03-12 , DOI: 10.1186/s13287-020-01604-y
Zhou Jiang 1 , Sijing Yu 1 , Hengyi Lin 1 , Ruiye Bi 2
Affiliation  

Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal criteria of the International Society for Cellular Therapy. Cartilage tissue is prone to injury and is difficult to repair. As cartilage-derived pluripotent cells are the closest cell source to cartilage tissue, they are expected to have the strongest ability to differentiate into cartilage compared to other MSCs. This review focuses on the organizational distribution, expression, and function of cartilage-derived pluripotent cells in joint development and repair to help explore the therapeutic potential of in situ cartilage-derived pluripotent cells for joint cartilage repair.

中文翻译:

软骨多能细胞在关节发育和修复中的表达和功能。

软骨衍生的多能细胞位于透明软骨和纤维软骨中。这些细胞具有多向分化的潜力。会发生脂肪形成,成骨和软骨形成; 并已被分类为符合国际细胞疗法学会最低标准的间充质干细胞(MSC)。软骨组织容易受伤,难以修复。由于软骨衍生的多能细胞是最接近软骨组织的细胞来源,因此与其他MSC相比,它们有望具有最强的分化为软骨的能力。这篇评论着重于组织分布,表达,
更新日期:2020-04-22
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