Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) differed between cases and non-cases of OT. Electronic repositories; PUBMED, EMBASE and Cochrane library were explored through December 2019 to retrieve published articles for inclusion in the meta-analysis after quality assessment. Heterogeneity was assessed using I2 statistics, the effect of individual studies on the overall effect size was tested using sensitivity analysis and funnel plot was used to evaluate publication bias. Twelve studies, involving 1767 OT cases and 229,167 non-cases of OT were included in this meta-analysis and I2 statistics ranged between 97 and 99%. Mean circulating TC (− 16.60 [− 32.43, − 0.77]mg/dL; P = 0.04) and HDL (− 0.25[− 0.43, − 0.08]mmol/L; P = 0.005) were significantly lower among OT cases compared to non-OT cases. Decreased TC and HDL profiles were observed among subjects with OT in this collection of reports. The implications of TC and HDL in tumour manifestations and growth need to be validated in a large multi-ethnic longitudinal cohort adjusting for relevant confounders.

中文翻译：

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脂质分布和卵巢肿瘤风险：一项荟萃分析

关于脂质分布与卵巢肿瘤（OT）之间关系的几份报告的现有数据提出了不同的结论。我们的目的是检查循环血脂水平：OT患者与非OT患者之间总胆固醇（TC），甘油三酸酯（TG），高密度脂蛋白（HDL）和低密度脂蛋白（LDL）是否有所不同。电子仓库；在2019年12月之前，对PUBMED，EMBASE和Cochrane库进行了探索，以检索发表的文章，并在进行质量评估后将其纳入Meta分析。使用I2统计量评估异质性，使用敏感性分析测试个别研究对整体效应大小的影响，并使用漏斗图评估发表偏倚。十二项研究涉及1767例OT病例和229例，这项荟萃分析包括167例非OT病例，I2统计量介于97％至99％之间。OT病例中的平均循环TC（-16.60 [-32.43，-0.77] mg / dL; P = 0.04）和HDL（-0.25 [-0.43，-0.08] mmol / L; P = 0.005）显着低于非-OT案例。在该报告集中，OT患者中的TC和HDL分布减少。TC和HDL在肿瘤表现和生长中的意义需要在针对相关混杂因素进行调整的大型多民族纵向队列中进行验证。