A semester-long research project for second-semester organic chemistry lab sections was developed. Student projects were based on preliminary data from faculty research that suggested the natural product neurolenin B to be a treatment for lymphatic filariasis. Students isolated neurolenins from the Central American plant Neurolaena lobata and proposed syntheses of previously unknown analogues using reactions learned in first- and second-semester organic chemistry. Using literature-based procedures, students ran reactions on neurolenins and analyzed their results by TLC and NMR spectroscopy. The semester culminated with a public poster session and final report using the Organic Letters template. Students in a total of 5 lab sections over 3 different semesters of the class completed this pilot course, and 15 sections in the same time span conducted traditional lab experiments. Qualitative and quantitative assessment data were collected to demonstrate the efficacy of the course. Students did not self-select into the pilot sections, were demographically similar to those in the traditional lab sections, and performed at the same level in the lecture portion of the course. Survey results from all students (traditional and pilot) were compared, and the students in the pilot sections showed higher levels of self-reported topic understanding, general motivation, and interest in organic chemistry.

中文翻译：

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第二学期有机化学学期-基于课程的长期研究项目：用于治疗被忽视的热带病的潜在铅化合物的合成

开发了一个为期一个学期的研究项目，用于第二学期有机化学实验室部分。学生项目基于教师研究的初步数据，该数据表明天然产物神经毒素B可作为淋巴丝虫病的治疗方法。学生从中美洲的植物Neurolaena lobata分离出神经亚麻素，并使用在第一学期和第二学期有机化学中学习到的反应，提出了以前未知的类似物的合成方法。使用基于文献的程序，学生对神经素进行反应，并通过TLC和NMR光谱分析其结果。本学期以公开海报发布会和使用有机信件的最终报告告终模板。在该课程的3个不同学期中，共有5个实验室部分的学生完成了该实验课程，并且在同一时间段内有15个部分进行了传统的实验室实验。收集定性和定量评估数据以证明该课程的有效性。学生没有自行选择进入试点部分，人口统计学上与传统实验室部分相似，并且在课程的授课部分中表现相同。比较了所有学生（传统学生和实验学生）的调查结果，实验部分的学生表现出较高水平的自我报告的主题理解，总体动机和对有机化学的兴趣。