当前位置:
X-MOL 学术
›
J. Cachexia Sarcopenia Muscle
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia.
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2020-03-11 , DOI: 10.1002/jcsm.12561 Sara Chiappalupi 1, 2 , Guglielmo Sorci 1, 2, 3 , Aleksandra Vukasinovic 1, 2 , Laura Salvadori 1, 2 , Roberta Sagheddu 1, 2 , Dario Coletti 4, 5 , Giorgia Renga 1 , Luigina Romani 1, 3 , Rosario Donato 1 , Francesca Riuzzi 1, 2
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2020-03-11 , DOI: 10.1002/jcsm.12561 Sara Chiappalupi 1, 2 , Guglielmo Sorci 1, 2, 3 , Aleksandra Vukasinovic 1, 2 , Laura Salvadori 1, 2 , Roberta Sagheddu 1, 2 , Dario Coletti 4, 5 , Giorgia Renga 1 , Luigina Romani 1, 3 , Rosario Donato 1 , Francesca Riuzzi 1, 2
Affiliation
Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end‐products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer.
中文翻译:
靶向 RAGE 可防止肌肉萎缩并延长癌症恶病质患者的生存期。
恶病质是一种多因素综合征,影响超过 50% 的晚期癌症患者,并导致约 20% 的癌症相关死亡,仍然是一个知之甚少的过程,没有可用的标准治愈方法。全身炎症引起的骨骼肌萎缩是恶病质的主要临床特征,导致体重减轻,降低患者的生活质量,降低患者对抗癌治疗的反应。RAGE(晚期糖基化终产物受体)是免疫球蛋白超家族的多配体受体,是肌肉再生、炎症和癌症的介质。
更新日期:2020-03-11
中文翻译:
靶向 RAGE 可防止肌肉萎缩并延长癌症恶病质患者的生存期。
恶病质是一种多因素综合征,影响超过 50% 的晚期癌症患者,并导致约 20% 的癌症相关死亡,仍然是一个知之甚少的过程,没有可用的标准治愈方法。全身炎症引起的骨骼肌萎缩是恶病质的主要临床特征,导致体重减轻,降低患者的生活质量,降低患者对抗癌治疗的反应。RAGE(晚期糖基化终产物受体)是免疫球蛋白超家族的多配体受体,是肌肉再生、炎症和癌症的介质。