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Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2020-03-11 , DOI: 10.1002/jhet.3956
Chander Prakash Kaushik 1 , Raj Luxmi 1
Affiliation  

Here, click synthesis of 15 naphthyl‐linked disubstituted 1,2,3‐triazoles has been carried out by the reaction between 1‐(prop‐2‐yn‐1‐yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, 1H NMR, 13C NMR, and HRMS techniques. Further, the compound 7f was confirmed by X‐ray crystallography (CCDC 1876891). The synthesized compounds were explored for antibacterial activity against Bacillus cereus , Escherichia coli , and Staphylococcus aureus . Biological evaluation of synthesized 1,2,3‐triazoles revealed moderate to good antibacterial activity against the tested strains. The antioxidative behavior of synthesized compounds manifested the remarkable free radical scavenging activity using DPPH assay.

中文翻译:

萘基连接的双取代的1,2,3-三唑的合成,抗菌和抗氧化活性

在这里,通过1-(prop-2-yn-1-yloxy)萘与芳族叠氮化物的反应进行了15个萘基连接的双取代1,2,3-三唑的点击合成。通过FTIR,1 H NMR,13 C NMR和HRMS技术进行合成化合物的结构阐明。此外,化合物7f通过X射线晶体学确认(CCDC 1876891)。探索了合成的化合物对蜡状芽孢杆菌大肠杆菌金黄色葡萄球菌的抗菌活性。。合成的1,2,3-三唑的生物学评估表明,对测试菌株的抗菌活性中等至良好。合成的化合物的抗氧化行为表现出显着的自由基清除活性,使用DPPH分析法。
更新日期:2020-03-11
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