Liquid phase transmission electron microscopy allows the imaging of materials in liquid environments. The sample is encapsulated within electron-beam transparent windows and hence protected by the ultra high vacuum necessary within the electron gun. Such an approach allows to study biological and soft materials in their natural environment and offers the possibility of accessing their dynamic nature. Yet, the electron beam scattering from the windows and solvent increases the image noise and blur. Herein, we propose a pipeline to both de-noise and sharpen images obtained by liquid transmission electron microscopy. We develop the workflow in a way that it does not require any human interference, nor introduce artefacts, but actually unveils features of the imaged samples covered by the noise and the blur. This article is protected by copyright. All rights reserved.

中文翻译：

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液相电子显微镜的端到端图像分析管道

液相透射电子显微镜可以对液体环境中的材料进行成像。样品被封装在电子束透明窗口内，因此受到电子枪内所需的超高真空的保护。这种方法允许在自然环境中研究生物和软材料，并提供访问其动态性质的可能性。然而，从窗口和溶剂散射的电子束会增加图像噪声和模糊。在此，我们提出了一种对液体透射电子显微镜获得的图像进行去噪和锐化的管道。我们以一种不需要任何人工干预的方式开发工作流程，也不需要引入人工制品，但实际上揭示了噪声和模糊覆盖的成像样本的特征。本文受版权保护。