Abstract

Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

摘要

丝素蛋白是一种主要的丝蛋白，具有理想的特性，可以作为药物的生物材料。近来，已经广泛研究了用于各种生物医学应用的纤维蛋白纳米颗粒（FNP）的开发。由于其多功能性和化学修饰性，FNP可以封装不同类型的治疗化合物，包括大小分子，蛋白质，酶，疫苗和遗传物质。此外，FNPs可以肠胃外和非胃肠外给药。这篇综述总结了关于丝和纤维蛋白来源和特性的基本信息，然后是有关FNP制备和表征方法的最新数据。此外，根据肠胃外，口服，经皮，眼，骨科和呼吸科。最后，讨论了这些系统的挑战和建议的解决方案以及未来的前景。